Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats
Identifieur interne : 000B01 ( Main/Exploration ); précédent : 000B00; suivant : 000B02Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats
Auteurs : C. Marin [Espagne] ; E. Aguilar [Espagne] ; G. Mengod [Espagne] ; R. Cortés [Espagne] ; J. A. Obeso [Espagne]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2009-09.
English descriptors
- KwdEn :
Abstract
We investigated the effect of early vs. late initiation of levodopa treatment on dyskinetic movements, rotational behavior and molecular markers in hemiparkinsonian rats. Male Sprague‐Dawley rats received a unilateral 6‐hydroxydopamine (6‐OHDA) administration in the nigrostriatal pathway. Rats were divided into three groups treated with: (i) levodopa (6 mg/kg) twice daily for 22 days starting at 4 weeks after 6‐OHDA (Early group); (ii) levodopa at the same dose, regimen and duration but starting at 12 weeks after 6‐OHDA (Late group), and (iii) saline starting at 4 weeks after 6‐OHDA and continuing until the Late group finished treatment. Dyskinesias were quantified on days 1 and 22 of levodopa treatment. Striatal expression of preproenkephalin and preprodynorphin mRNAs, subthalamic cytochrome oxidase mRNA, and glutamate decarboxylase 67 mRNA in the pars reticulata of the substantia nigra was measured by in‐situ hybridization. After 22 days of levodopa treatment, the percentage of rats showing dyskinesia was lower in the Early group than in the Late group (60% vs. 100%, respectively). No significant differences in total dyskinesia score were observed between both groups with the exception of the orolingual dyskinesias that were significantly less frequent in the Late group (P < 0.01). No significant differences were observed in the molecular markers between the Early and Late groups. Prompt initiation of levodopa treatment might be able to delay some of the basal ganglia molecular and circuitry changes underlying the development of dyskinesia but, once developed, they are behaviorally and molecularly similar to those appearing after late initiation of levodopa.
Url:
DOI: 10.1111/j.1460-9568.2009.06877.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats</title>
<author><name sortKey="Marin, C" sort="Marin, C" uniqKey="Marin C" first="C." last="Marin">C. Marin</name>
</author>
<author><name sortKey="Aguilar, E" sort="Aguilar, E" uniqKey="Aguilar E" first="E." last="Aguilar">E. Aguilar</name>
</author>
<author><name sortKey="Mengod, G" sort="Mengod, G" uniqKey="Mengod G" first="G." last="Mengod">G. Mengod</name>
</author>
<author><name sortKey="Cortes, R" sort="Cortes, R" uniqKey="Cortes R" first="R." last="Cortés">R. Cortés</name>
</author>
<author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4A6A06C91F1F3530840C34314FA70C6B5BE2F93A</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1111/j.1460-9568.2009.06877.x</idno>
<idno type="url">https://api.istex.fr/document/4A6A06C91F1F3530840C34314FA70C6B5BE2F93A/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001004</idno>
<idno type="wicri:Area/Main/Curation">000E18</idno>
<idno type="wicri:Area/Main/Exploration">000B01</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats</title>
<author><name sortKey="Marin, C" sort="Marin, C" uniqKey="Marin C" first="C." last="Marin">C. Marin</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori de Neurologia Experimental, Àrea de Neurociències, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Redes sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aguilar, E" sort="Aguilar, E" uniqKey="Aguilar E" first="E." last="Aguilar">E. Aguilar</name>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratori de Neurologia Experimental, Àrea de Neurociències, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mengod, G" sort="Mengod, G" uniqKey="Mengod G" first="G." last="Mengod">G. Mengod</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Redes sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Neuroquímica i Neurofarmacologia, Institut d’Investigacions Biomèdiques de Barcelona, CSIC‐IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cortes, R" sort="Cortes, R" uniqKey="Cortes R" first="R." last="Cortés">R. Cortés</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Redes sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departament de Neuroquímica i Neurofarmacologia, Institut d’Investigacions Biomèdiques de Barcelona, CSIC‐IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Redes sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology and Neurosurgery, Neuroscience Center, Clínica Universitaria and Medical School, University of Navarra and CIMA, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Neuroscience</title>
<idno type="ISSN">0953-816X</idno>
<idno type="eISSN">1460-9568</idno>
<imprint><publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2009-09">2009-09</date>
<biblScope unit="volume">30</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="823">823</biblScope>
<biblScope unit="page" to="832">832</biblScope>
</imprint>
<idno type="ISSN">0953-816X</idno>
</series>
<idno type="istex">4A6A06C91F1F3530840C34314FA70C6B5BE2F93A</idno>
<idno type="DOI">10.1111/j.1460-9568.2009.06877.x</idno>
<idno type="ArticleID">EJN6877</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0953-816X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term>
<term>cytochrome oxidase</term>
<term>dyskinesias</term>
<term>levodopa</term>
<term>preprodynorphin</term>
<term>preproenkephalin</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We investigated the effect of early vs. late initiation of levodopa treatment on dyskinetic movements, rotational behavior and molecular markers in hemiparkinsonian rats. Male Sprague‐Dawley rats received a unilateral 6‐hydroxydopamine (6‐OHDA) administration in the nigrostriatal pathway. Rats were divided into three groups treated with: (i) levodopa (6 mg/kg) twice daily for 22 days starting at 4 weeks after 6‐OHDA (Early group); (ii) levodopa at the same dose, regimen and duration but starting at 12 weeks after 6‐OHDA (Late group), and (iii) saline starting at 4 weeks after 6‐OHDA and continuing until the Late group finished treatment. Dyskinesias were quantified on days 1 and 22 of levodopa treatment. Striatal expression of preproenkephalin and preprodynorphin mRNAs, subthalamic cytochrome oxidase mRNA, and glutamate decarboxylase 67 mRNA in the pars reticulata of the substantia nigra was measured by in‐situ hybridization. After 22 days of levodopa treatment, the percentage of rats showing dyskinesia was lower in the Early group than in the Late group (60% vs. 100%, respectively). No significant differences in total dyskinesia score were observed between both groups with the exception of the orolingual dyskinesias that were significantly less frequent in the Late group (P < 0.01). No significant differences were observed in the molecular markers between the Early and Late groups. Prompt initiation of levodopa treatment might be able to delay some of the basal ganglia molecular and circuitry changes underlying the development of dyskinesia but, once developed, they are behaviorally and molecularly similar to those appearing after late initiation of levodopa.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Catalogne"><name sortKey="Marin, C" sort="Marin, C" uniqKey="Marin C" first="C." last="Marin">C. Marin</name>
</region>
<name sortKey="Aguilar, E" sort="Aguilar, E" uniqKey="Aguilar E" first="E." last="Aguilar">E. Aguilar</name>
<name sortKey="Cortes, R" sort="Cortes, R" uniqKey="Cortes R" first="R." last="Cortés">R. Cortés</name>
<name sortKey="Cortes, R" sort="Cortes, R" uniqKey="Cortes R" first="R." last="Cortés">R. Cortés</name>
<name sortKey="Marin, C" sort="Marin, C" uniqKey="Marin C" first="C." last="Marin">C. Marin</name>
<name sortKey="Mengod, G" sort="Mengod, G" uniqKey="Mengod G" first="G." last="Mengod">G. Mengod</name>
<name sortKey="Mengod, G" sort="Mengod, G" uniqKey="Mengod G" first="G." last="Mengod">G. Mengod</name>
<name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name>
<name sortKey="Obeso, J A" sort="Obeso, J A" uniqKey="Obeso J" first="J. A." last="Obeso">J. A. Obeso</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B01 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B01 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:4A6A06C91F1F3530840C34314FA70C6B5BE2F93A |texte= Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats }}
This area was generated with Dilib version V0.6.23. |